Straily burst onto the big league scene with Oakland in August of 2012, going 2-1 in seven starts for the Athletics. Dan went 10-8 with a 3.96 ERA in 2013 and finished fourth in A.L. Rookie of the Year balloting. Traded to the Cubs the following season, Straily fell on hard times in Chicago and was dealt to Houston in January of 2015.

The righthander from Redlands, CA, pitched in four games (three starts) as an Astro, posting an 0-1 record and 5.40 ERA. Just before the 2016 season, he was traded to San Diego for catcher Erik Kratz.

Straily's up-and-down career continued in Cincinnati where he won 14 games and Miami where he won 10 games before suffering another downturn the next two years. Through 2019, the pitcher has a 44-40 record with a 4.56 ERA over 156 games (140 starts).