Acquired just before the start of the 2009 season, the versatile Keppinger played for the Mets, Royals and Reds before joining the Astros. He split time at third base the first year then won the job at second base in 2010, leading the club in batting average and doubles.

The veteran was dealt midway through the 2011 season to San Francisco for two pitching prospects. Keppinger finished his nine-year career with the Rays and White Sox. Overall, he batted .282 with 45 homers and a .714 OPS.