The righthander from Springfield, MO was claimed off waivers from the White Sox in 2011 and had a career year with a terrible Astros team in 2012, going 11-11 with a 3.76 ERA. He fueded with the new analytical management over defensive shifting the next season and led the league in losses.

After getting his release in 2014, Harrell pitched briefly with the Braves, Rangers and Blue Jays. When his career ended, he had a record of 21-35 with a 4.85 ERA.