The Dominican hurler was acquired from the Cincinnati Reds late in the 2010 campaign and spent all of 2011 in the Astros bullpen. After time spent in the minors changing his delivery in 2012, Enerio returned for 19 games.

As an Astro, he posted a 0-3 mark and a 6.01 ERA in 75 appearances. Overall, his big league record was 1-4 with a 5.60 ERA.