A late-season waiver acquisition, Castillo saw limited action during the 2008 season. A veteran of the Pirates and Giants, the Venezuelan infielder hit .281 in 15 games.

Castillo died at age 37 on December 6, 2018 in Yaracuy, Venezuela, in an auto accident caused by an obstacle placed in the road by highway robbers. Former Astro Luis Valbuena died in the same incident.