| Player | Pos | Seasons | Born | Birthplace | |
| Kirk Saarloos | P | 2002-03 | May 23, 1979 | Long Beach | CA |
| Mark Saccomanno | 1B | 2008 | Apr 30, 1980 | Houston | TX |
| Billy Sadler | P | 2009 | Sep 21, 1981 | Pensacola | FL |
| Joe Sambito | P | 1976-82, 1984 | Jun 28, 1952 | Brooklyn | NY |
| Chris Sampson | P | 2006-10 | May 23, 1978 | Pasadena | TX |
| Carlos Sanabria | P | 2020 | Jan 24, 1997 | La Victoria | VZ |
| Aaron Sanchez | P | 2019 | Jul 1, 1992 | Barstow | CA |
| Angel Sánchez | SS/2B | 2010-11 | Sep 20, 1983 | Humacao | PR |
| Domingo Santana | OF | 2014-15 | Aug 5, 1992 | Santo Domingo | DR |
| Dennis Sarfate | P | 2007 | Apr 9, 1981 | Queens | NY |
| Bob Scanlan | P | 1998 | Aug 9, 1966 | Los Angeles | CA |
| Jordan Schafer | OF | 2011-12 | Sep 4, 1986 | Hammond | IN |
| Dan Schatzeder | P | 1989-90 | Dec 1, 1954 | Elmhurst | IL |
| Rich Scheid | P | 1992 | Feb 3, 1965 | Staten Island | NY |
| Fred Scherman | P | 1974-75 | Jul 25, 1944 | Dayton | OH |
| Curt Schilling | P | 1991 | Nov 14, 1966 | Anchorage | AK |
| Jay Schlueter | OF | 1971 | Jul 31, 1949 | Phoenix | AZ |
| Dan Schneider | P | 1967, 1969 | Aug 29, 1942 | Evansville | IN |
| Pete Schourek | P | 1998 | May 10, 1969 | Austin | TX |
| Luke Scott | OF | 2005-07 | Jun 25, 1978 | De Leon Springs | FL |
| Mike Scott | P | 1983-91 | Apr 26, 1955 | Santa Monica | CA |
| Tony Scott | OF | 1981-84 | Sep 18, 1951 | Cincinnati | OH |
| Andre Scrubb | P | 2020-21 | Jan 13, 1995 | Fort Bragg | NC |
| Todd Self | OF | 2005 | Nov 9, 1978 | Shreveport | LA |
| Carroll Sembera | P | 1965-67 | Jul 26, 1941 | Shiner | TX |
| Scott Servais | C | 1991-95, 2001 | Jun 4, 1967 | La Crosse | WI |
| Jimmy Sexton | SS | 1978-79 | Dec 15, 1951 | Mobile | AL |
| Bobby Shantz | P | 1962 | Sep 26, 1925 | Pottstown | PA |
| Steve Shea | P | 1968 | Dec 5, 1942 | Worcester | MA |
| Larry Sherry | P | 1967 | Jul 25, 1935 | Los Angeles | CA |
| Craig Shipley | 3B/SS | 1995 | Jan 7, 1963 | Parramatta | AU |
| J.B. Shuck | OF | 2011 | Jun 18, 1987 | Westerville | OH |
| Paul Siebert | P | 1974-76 | Jun 5, 1953 | Minneapolis | MN |
| Mike Simms | OF/1B | 1990-92, 1994-96 | Jan 12, 1967 | Orange | CA |
| Dick Simpson | OF | 1968 | Jul 28, 1943 | Washington | DC |
| Greg Sims | OF | 1966 | Jun 28, 1946 | San Francisco | CA |
| Jon Singleton | 1B | 2014-15 | Sep 18, 1991 | Harbor City | CA |
| Tony Sipp | P | 2014-18 | Jul 12, 1983 | Pascagoula | MS |
| Jose Siri | OF | 2021 | Jul 22, 1995 | Sabana Grande de Boya | DR |
| Joe Slusarski | P | 1999-2001 | Dec 19, 1966 | Indianapolis | IN |
| Craig Smajstrla | 2B | 1988 | Jun 19, 1962 | Houston | TX |
| Mark Small | P | 1996 | Nov 12, 1967 | Portland | OR |
| Billy Smith | P | 1981 | Sep 13, 1954 | La Marque | TX |
| Dave Smith | P | 1980-90 | Jan 21, 1955 | Richmond | CA |
| Hal Smith | C | 1962-63 | Dec 7, 1930 | West Frankfort | IL |
| Jason Smith | 2B | 2009 | Jul 24, 1977 | Meridian | MS |
| Joe Smith | P | 2018-19, 2021 | Mar 22, 1984 | Cincinnati | OH |
| Cy Sneed | P | 2019-20 | Oct 1, 1992 | Elko | NV |
| Chris Snyder | C | 2012 | Feb 12, 1981 | Houston | TX |
| Julio Solano | P | 1983-87 | Jan 8, 1960 | Agua Blanca | DR |
| Peter Solomon | P | 2021 | Aug 16, 1996 | Washington | DC |
| Henry Sosa | P | 2011 | Jul 28, 1985 | El Seibo | DR |
| José Sosa | P | 1975-76 | Dec 28, 1952 | Santo Domingo | DR |
| Al Spangler | OF | 1962-65 | Jul 8, 1933 | Philadelphia | PA |
| Rob Sperring | 2B/SS/3B | 1977 | Oct 10, 1949 | San Francisco | CA |
| Bill Spiers | 3B/SS | 1996-2001 | Jun 5, 1966 | Orangeburg | SC |
| Harry Spilman | 1B/C | 1981-85, 1988-89 | Jul 18, 1954 | Albany | GA |
| Scipio Spinks | P | 1969-71 | Jul 12, 1947 | Chicago | IL |
| George Springer | OF | 2014-20 | Sep 19, 1989 | New Britain | CT |
| Russ Springer | P | 1997, 2004-06 | Nov 7, 1968 | Alexandria | LA |
| Bobby Sprowl | P | 1979-81 | Apr 14, 1956 | Sandusky | OH |
| Ryne Stanek | P | 2021 | Jul 26, 1991 | St. Louis | MO |
| Andy Stankiewicz | SS/2B | 1994-95 | Aug 10, 1964 | Inglewood | CA |
| Mike Stanton | P | 1975 | Sep 25, 1952 | St. Louis | MO |
| Max Stassi | C | 2013-19 | Mar 15, 1991 | Woodland | CA |
| Rusty Staub | OF/1B | 1963-68 | Apr 1, 1944 | New Orleans | LA |
| Jimmy Stewart | 3B/1B/2B/OF | 1972-73 | Jun 11, 1939 | Opelika | AL |
| Bob Stinson | C/OF | 1972 | Oct 11, 1945 | Elkin | NC |
| Dean Stone | P | 1962 | Sep 1, 1930 | Moline | IL |
| Ricky Stone | P | 2001-04 | Feb 28, 1975 | Hamilton | OH |
| Mickey Storey | P | 2012 | Mar 16, 1986 | Fort Lauderdale | FL |
| Dan Straily | P | 2015 | Dec 1, 1988 | Redlands | CA |
| Myles Straw | OF/SS | 2018-21 | Oct 17, 1994 | Garden Grove | CA |
| Scott Strickland | P | 2005 | Apr 26, 1976 | Houston | TX |
| Franklin Stubbs | 1B/OF | 1990 | Oct 21, 1960 | Laurinburg | NC |
| Garrett Stubbs | C/OF | 2019-21 | May 26, 1993 | San Diego | CA |
| Cory Sullivan | OF | 2010 | Aug 20, 1979 | Tulsa | OK |
| Gary Sutherland | 2B | 1972-73 | Sep 27, 1944 | Glendale | CA |
| Don Sutton | P | 1981-82 | Apr 2, 1945 | Clio | AL |
| Greg Swindell | P | 1993-96 | Jan 2, 1965 | Fort Worth | TX |