| Player | Pos | Seasons | Born | Birthplace | |
| Arnold Earley | P | 1967 | Jun 4, 1933 | Lincoln Park | MI |
| Mike Easler | OF | 1973-75 | Nov 29, 1950 | Cleveland | OH |
| Tom Edens | P | 1993-94 | Jun 9, 1961 | Ontario | OR |
| Johnny Edwards | C | 1969-74 | Jun 10, 1938 | Columbus | OH |
| Dave Eilers | P | 1967 | Dec 3, 1936 | Oldenburg | TX |
| Scott Elarton | P | 1998-2001 | Feb 23, 1976 | Lamar | CO |
| Jake Elmore | SS/2B/DH/OF | 2013 | Jun 15, 1987 | Dothan | AL |
| Kent Emanuel | P | 2021 | Jun 4, 1992 | Woodstock | GA |
| Morgan Ensberg | 3B | 2000, 2002-07 | Aug 26, 1975 | Redondo Beach | CA |
| Darin Erstad | OF/1B | 2008-09 | Jun 4, 1974 | Jamestown | ND |
| Sergio Escalona | P | 2011 | Aug 3, 1984 | El Tocuyo | VZ |
| Brian Esposito | C | 2010 | Feb 24, 1979 | Staten Island | NY |
| Tony Eusebio | C | 1991, 1994-2001 | Apr 27, 1967 | Los Llanos | DR |
| Adam Everett | SS | 2001-07 | Feb 2, 1977 | Austell | GA |
| Carl Everett | OF | 1998-99 | Jun 3, 1971 | Tampa | FL |