| Player | Pos | Seasons | Born | Birthplace | |
| Enos Cabell | 3B/1B | 1975-80, 1984-85 | Oct 8, 1949 | Fort Riley | KS |
| José Cabrera | P | 1997-2000 | Mar 24, 1972 | La Delgada | DR |
| Craig Cacek | 1B | 1977 | Sep 10, 1954 | Los Angeles | CA |
| Jeff Calhoun | P | 1984-86 | Apr 11, 1958 | La Grange | GA |
| Ernie Camacho | P | 1988 | Feb 1, 1955 | Salinas | CA |
| Ken Caminiti | 3B | 1987-94, 1999-2000 | Apr 21, 1963 | Hanford | CA |
| Dave Campbell | 3B/2B/1B | 1973-74 | Jan 14, 1942 | Manistee | MI |
| Jim Campbell | C | 1962-63 | Jun 24, 1937 | Palo Alto | CA |
| Robinson Cancel | C | 2011 | May 4, 1976 | Lajas | PR |
| Casey Candaele | 2B/OF/SS/3B | 1988, 1990-93 | Jan 12, 1961 | Lompoc | CA |
| John Cangelosi | OF | 1995-96 | Mar 10, 1963 | Brooklyn | NY |
| Joe Cannon | OF | 1977-78 | Jul 13, 1953 | Camp LeJeune | NC |
| José Canó | P | 1989 | Mar 7, 1962 | Boca del Soco | DR |
| Mike Capel | P | 1991 | Oct 13, 1961 | Marshall | TX |
| George Cappuzzello | P | 1982 | Jan 15, 1954 | Youngstown | OH |
| Conrad Cardinal | P | 1963 | Mar 30, 1942 | Brooklyn | NY |
| David Carpenter | P | 2011-12 | Jul 15, 1985 | Morgantown | WV |
| Frank Carpin | P | 1966 | Sep 14, 1938 | Brooklyn | NY |
| Chuck Carr | OF | 1997 | Aug 10, 1967 | San Bernardino | CA |
| Chris Carter | DH/1B/OF | 2013-15 | Dec 18, 1986 | Redwood City | CA |
| Kevin Cash | C | 2010 | Dec 6, 1977 | Tampa | FL |
| Jack Cassel | P | 2008 | Aug 8, 1980 | Los Angeles | CA |
| Humberto Castellanos | P | 2020 | Apr 3, 1998 | Tepatitlan | MX |
| Vinny Castilla | 3B | 2001 | Jul 4, 1967 | Oaxaca | MX |
| José Castillo | 3B/2B | 2008 | Mar 19, 1981 | Las Mercedes | VZ |
| Jason Castro | C | 2010, 2012-16, 2021 | Jun 18, 1987 | Castro Valley | CA |
| Andújar Cedeño | SS | 1990-94, 1996 | Aug 21, 1969 | La Romana | DR |
| César Cedeño | OF | 1970-81 | Feb 25, 1951 | Santo Domingo | DR |
| Roger Cedeño | OF | 2000 | Aug 16, 1974 | Valencia | VZ |
| Ronny Cedeño | SS/DH | 2013 | Feb 2, 1983 | Puerto Cabello | VZ |
| Xavier Cedeño | P | 2011-13 | Aug 26, 1986 | Guayanilla | PR |
| Juan Centeno | C | 2017 | Nov 16, 1989 | Arecibo | PR |
| Bob Cerv | OF | 1962 | May 5, 1925 | Weston | NE |
| Gustavo Chacin | P | 2010 | Dec 4, 1980 | Maracaibo | VZ |
| Shawn Chacon | P | 2008 | Dec 23, 1977 | Anchorage | AK |
| Kevin Chapman | P | 2013-16 | Feb 19, 1988 | Coral Springs | FL |
| Frank Charles | C | 2000 | Feb 23, 1969 | Fontana | CA |
| Raúl Chávez | C | 2000, 2002-05 | Mar 17, 1973 | Valencia | VZ |
| Bruce Chen | P | 2003 | Jun 19, 1977 | Panama | PN |
| Rocky Childress | P | 1987-88 | Feb 18, 1962 | Santa Rosa | CA |
| Rich Chiles | OF | 1971-72, 1976 | Nov 22, 1949 | Sacramento | CA |
| Robinson Chirinos | C | 2019 | Jun 5, 1984 | Punto Fijo | VZ |
| Al Cicotte | P | 1962 | Dec 23, 1929 | Melvindale | MI |
| José Cisnero | P | 2013-14 | Apr 11, 1989 | Bajos de Haina | DR |
| Jim Clancy | P | 1989-91 | Dec 18, 1955 | Chicago | IL |
| Cody Clark | C | 2013 | Sep 14, 1981 | Fayetteville | AR |
| Dave Clark | OF/DH | 1998 | Sep 3, 1962 | Tupelo | MS |
| Terry Clark | P | 1990, 1996 | Oct 18, 1960 | Los Angeles | CA |
| Paul Clemens | P | 2013-14 | Feb 14, 1988 | Columbia | SC |
| Roger Clemens | P | 2004-06 | Aug 4, 1962 | Dayton | OH |
| Tyler Clippard | P | 2017 | Feb 14, 1985 | Lexington | KY |
| Nate Colbert | OF/1B | 1966, 1968 | Apr 9, 1946 | St. Louis | MO |
| Gerrit Cole | P | 2018-19 | Sep 8, 1990 | Newport Beach | CA |
| Hank Conger | C | 2015 | Jan 29, 1988 | Federal Way | WA |
| Ron Cook | P | 1970-71 | Jul 11, 1947 | Jefferson | TX |
| Danny Coombs | P | 1963-69 | Mar 23, 1942 | Lincoln | ME |
| Gary Cooper | 3B | 1991 | Aug 13, 1964 | Lynwood | CA |
| Francisco Cordero | P | 2012 | May 11, 1975 | Santo Domingo | DR |
| Carlos Corporán | C | 2011-14 | Jan 7, 1984 | Hato Rey | PR |
| Carlos Correa | SS | 2015-21 | Sep 22, 1994 | Ponce | PR |
| Jim Corsi | P | 1991 | Sep 9, 1961 | Newton | MA |
| Jarred Cosart | P | 2013-14 | May 25, 1990 | League City | TX |
| Mike Cosgrove | P | 1972-76 | Feb 17, 1951 | Phoenix | AZ |
| Chris Coste | C/1B | 2009 | Feb 4, 1973 | Fargo | ND |
| Jim Crawford | P | 1973, 1975 | Sep 29, 1950 | Chicago | IL |
| Willie Crawford | OF | 1977 | Sep 7, 1946 | Los Angeles | CA |
| Tripp Cromer | SS/3B/2B | 2000, 2003 | Nov 21, 1967 | Lake City | SC |
| Trevor Crowe | OF | 2013 | Nov 17, 1983 | Portland | OR |
| José Cruz | OF | 1975-87 | Aug 8, 1947 | Arroyo | PR |
| José L. Cruz | OF | 2008 | Apr 19, 1974 | Arroyo | PR |
| Nelson Cruz | P | 2001-02 | Sep 13, 1972 | Puerto Plata | DR |
| Rhiner Cruz | P | 2012-13 | Nov 1, 1986 | Santo Domingo | DR |
| Mike Cuellar | P | 1965-68 | May 8, 1937 | Las Villas | CU |
| George Culver | P | 1970-72 | Jul 8, 1943 | Salinas | CA |