| Player | Pos | Seasons | Born | Birthplace | |
| Brandon Backe | P | 2004-09 | Apr 5, 1978 | Galveston | TX |
| Pedro Báez | P | 2021 | Mar 11, 1988 | Bani | DR |
| Jeff Bagwell | 1B | 1991-2005 | May 27, 1968 | Boston | MA |
| Brandon Bailey | P | 2020 | Oct 19, 1994 | Westminster | CO |
| Mark Bailey | C | 1984-88 | Nov 4, 1961 | Springfield | MO |
| Paul Bako | C | 1999-2000 | Jun 20, 1972 | Lafayette | LA |
| Jeff Baldwin | OF | 1990 | Sep 5, 1965 | Milford | DE |
| Reggie Baldwin | C | 1978-79 | Aug 19, 1954 | River Rouge | MI |
| Lee Bales | 2B/SS | 1967 | Dec 4, 1944 | Los Angeles | CA |
| Josh Banks | P | 2010 | Jul 18, 1982 | Baltimore | MD |
| Alan Bannister | SS/OF | 1984 | Sep 3, 1951 | Montebello | CA |
| Floyd Bannister | P | 1977-78 | Jun 10, 1955 | Pierre | SD |
| Glen Barker | OF | 1999-2001 | May 10, 1971 | Albany | NY |
| Mike Barlow | P | 1976 | Apr 30, 1948 | Stamford | NY |
| Clint Barmes | SS | 2011 | Mar 6, 1979 | Vincennes | IN |
| Brandon Barnes | OF | 2012-13 | May 15, 1986 | Orange | CA |
| Manuel Barrios | P | 1997 | Sep 21, 1974 | Cabecera | PN |
| Philip Barzilla | P | 2006 | Jan 25, 1979 | Houston | TX |
| Anthony Bass | P | 2014 | Nov 1, 1987 | Dearborn | MI |
| Kevin Bass | OF | 1982-89, 1993-94 | May 12, 1959 | Redwood City | CA |
| John Bateman | C | 1963-68 | Jul 21, 1940 | Fort Sill | OK |
| Rafael Batista | 1B | 1973, 1975 | Nov 25, 1945 | San Pedro de Macoris | DR |
| Yorman Bazardo | P | 2009 | Jul 11, 1984 | Maracay | VZ |
| Jim Beauchamp | OF/1B | 1964-65, 1970 | Aug 21, 1939 | Vinita | OK |
| Erik Bedard | P | 2013 | Mar 5, 1979 | Navan | CN |
| Bo Belinsky | P | 1967 | Dec 7, 1936 | New York | NY |
| Buddy Bell | 3B | 1988 | Aug 27, 1951 | Pittsburgh | PA |
| Derek Bell | OF | 1995-99 | Dec 11, 1968 | Tampa | FL |
| Eric Bell | P | 1993 | Oct 27, 1963 | Modesto | CA |
| Carlos Beltrán | DH/OF | 2004, 2017 | Apr 24, 1977 | Manati | PR |
| Dave Bergman | 1B/OF | 1978-81 | Jun 6, 1953 | Evanston | IL |
| Sean Bergman | P | 1998-99 | Apr 11, 1970 | Joliet | IL |
| Lance Berkman | OF/1B | 1999-2010 | Feb 10, 1976 | Waco | TX |
| Dale Berra | SS | 1987 | Dec 13, 1956 | Ridgewood | NJ |
| Sean Berry | 3B | 1996-98 | Mar 22, 1966 | Santa Monica | CA |
| Joe Biagini | P | 2019-20 | May 29, 1990 | Menlo Park | CA |
| Buddy Biancalana | SS | 1987 | Feb 2, 1960 | Greenbrae | CA |
| Brandon Bielak | P | 2020-21 | Apr 2, 1996 | Edison | NJ |
| Craig Biggio | 2B/C/OF | 1988-2007 | Dec 14, 1965 | Smithtown | NY |
| Jack Billingham | P | 1969-71 | Feb 21, 1943 | Orlando | FL |
| Brian Bixler | OF/SS/2B | 2012 | Oct 22, 1982 | Sandusky | OH |
| George Bjorkman | C | 1983 | Aug 26, 1956 | Ontario | CA |
| Travis Blackley | P | 2013 | Nov 4, 1982 | Melbourne | AU |
| Willie Blair | P | 1992 | Dec 18, 1965 | Paintsville | KY |
| Nate Bland | P | 2003 | Dec 27, 1974 | Birmingham | AL |
| Wade Blasingame | P | 1967-72 | Nov 22, 1943 | Deming | NM |
| Curt Blefary | 1B | 1969 | Jul 5, 1943 | Brooklyn | NY |
| Geoff Blum | 3B | 2002-03, 2008-10 | Apr 26, 1973 | Redwood City | CA |
| Bruce Bochy | C | 1978-80 | Apr 16, 1955 | Landes de Bussac | FR |
| Joe Boever | P | 1992 | Oct 4, 1960 | Kirkwood | MO |
| Tim Bogar | SS | 1997-2000 | Oct 28, 1966 | Indianapolis | IN |
| Brian Bogusevic | OF | 2010-12 | Feb 18, 1984 | Oak Lawn | IL |
| Walt Bond | 1B/OF | 1964-65 | Oct 19, 1937 | Denmark | TN |
| Aaron Boone | 1B/3B | 2009 | Mar 9, 1973 | La Mesa | CA |
| Danny Boone | P | 1982 | Jan 14, 1954 | Long Beach | CA |
| Pedro Borbón | P | 2002 | Nov 15, 1967 | Mao | DR |
| Pat Borders | C | 1995 | May 14, 1963 | Columbus | OH |
| Dave Borkowski | P | 2006-08 | Feb 7, 1977 | Detroit | MI |
| Ken Boswell | 3B/2B | 1975-77 | Feb 23, 1946 | Austin | TX |
| Kent Bottenfield | P | 2001 | Nov 14, 1968 | Portland | OR |
| Jason Bourgeois | OF | 2010-11 | Jan 4, 1982 | Houston | TX |
| Michael Bourn | OF | 2008-11 | Dec 27, 1982 | Houston | TX |
| Jim Bouton | P | 1969-70 | Mar 8, 1939 | Newark | NJ |
| Ryan Bowen | P | 1991-92 | Feb 10, 1968 | Hanford | CA |
| Don Bradey | P | 1964 | Oct 4, 1934 | Charlotte | NC |
| Ron Brand | C | 1965-68 | Jan 13, 1940 | Los Angeles | CA |
| Jackie Brandt | 1B/OF | 1967 | Apr 28, 1934 | Omaha | NE |
| Michael Brantley | OF/DH | 2019-21 | May 15, 1987 | Bellevue | WA |
| Sid Bream | 1B | 1994 | Aug 3, 1960 | Carlisle | PA |
| Alex Bregman | 3B/SS | 2016-21 | Mar 30, 1994 | Albuquerque | NM |
| Doug Brocail | P | 1995-96, 2008-09 | May 16, 1967 | Clearfield | PA |
| Hal Brown | P | 1963-64 | Dec 11, 1924 | Greensboro | NC |
| Ollie Brown | OF | 1974 | Feb 11, 1944 | Tuscaloosa | AL |
| Byron Browne | OF | 1968 | Dec 27, 1942 | St. Joseph | MO |
| Pidge Browne | 1B | 1962 | Mar 21, 1929 | Peekskill | NY |
| Bob Bruce | P | 1962-66 | May 16, 1933 | New York | NY |
| Mike Brumley | OF/SS/3B | 1993, 1995 | Apr 9, 1963 | Oklahoma City | OK |
| George Brunet | P | 1962-63 | Jun 8, 1935 | Houghton | MI |
| Eric Bruntlett | SS/OF/2B | 2003-07 | Mar 29, 1978 | Lafayette | IN |
| Don Bryant | C | 1969-70 | Jul 13, 1941 | Jasper | FL |
| Jake Buchanan | P | 2014-15 | Sep 24, 1989 | Charlotte | NC |
| Taylor Buchholz | P | 2006 | Oct 13, 1981 | Lower Merion | PA |
| Travis Buck | OF | 2012 | Nov 18, 1983 | Richland | WA |
| Don Buddin | SS/3B | 1962 | May 5, 1934 | Turbeville | SC |
| Kirk Bullinger | P | 2003-04 | Oct 28, 1969 | New Orleans | LA |
| Eric Bullock | OF | 1985-86 | Feb 16, 1960 | Los Angeles | CA |
| Chris Burke | OF/2B | 2004-07 | Mar 11, 1980 | Louisville | KY |
| Mike Burns | P | 2005 | Jul 14, 1978 | Westminster | CA |
| Jim Busby | OF | 1962 | Jan 8, 1927 | Kenedy | TX |
| Ray Busse | 3B/SS | 1971, 1973-74 | Sep 25, 1948 | Daytona Beach | FL |
| John Buzhardt | P | 1967-68 | Aug 17, 1936 | Prosperity | SC |
| Tim Byrdak | P | 2008-10 | Oct 31, 1973 | Oak Lawn | IL |